منابع مشابه
Asymmetric synthesis of alpha-aminophosphonates using the inexpensive chiral catalyst 1,1'-binaphthol phosphate.
Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3'-[4-fluorophenyl](2)-1,1'-binaphthol phosphate has been found effective to give new alpha-amino-phosphonates 9 in moderate yields (30-65%) and enantiomeric excess (8.4%-61.9%).
متن کاملChelating Tendencies of Bioactive Aminophosphonates
The metal-binding abilities of a wide variety of bioactive aminophosphonates, from the simple aminoethanephosphonic acids to the rather large macrocyclic polyaza derivatives, are discussed with special emphasis on a comparison of the analogous carboxylic acid and phosphonic acid systems. Examples are given of the biological importance of metal ion - aminophosphonate interactions in living syste...
متن کاملMembrane-active aminophosphonates.
Xenobiotic exposure may induce cell membrane injury which would affect cellular structures and function. This study examined the influence of new aminophosphonates, synthesized for agrochemical application, on biological and model membranes properties. The aminophosphonates differed in the substituents on their carbon, nitrogen and phosphorus atoms. Measurements were made of the stability of pl...
متن کاملOne pot synthesis of alpha-aminophosphonates containing bromo and 3,4,5-trimethoxybenzyl groups under solvent-free conditions.
New alpha-aminophosphonates were synthesized by the Kabachnik-Fields reaction of 3,4,5-trimethoxybenzaldehyde (TMB) with p- or m-bromoaniline and a dialkyl phosphite under solvent-free conditions. TMB was prepared from gallic acid via a four step synthetic sequence involving etherification, esterification, hydrazidation and potassium ferricyanide oxidation. The structures of all synthesized com...
متن کاملSynthesis of Biologically Active -Aminophosphonates
Abstract: Highly convergent Synthesis of -aminophosphonates were most conveniently achieved using organophosphorus chemistry. Synthesis of -aminophosphonates were accomplished by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These aminophosphonates exhibited promising antimicrobial, antioxidant and anticancer activity. Some recent developments and applications to th...
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ژورنال
عنوان ژورنال: Revista dos Trabalhos de Iniciação Científica da UNICAMP
سال: 2019
ISSN: 2596-1969
DOI: 10.20396/revpibic262018754